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Xelix SR

Xelix SR

Indapamide

Indapamide is a diuretic antihypertensive. It appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. It has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Product Details

Presentation

Xelix SR Tablet: Each sustained release tablet contains Indapamide USP 1.5 mg

Pharmacology

Indapamide is a diuretic antihypertensive. It appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. It has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Indication

•Essential hypertension
•Salt and fluid retention associated with congestive heart failure

Dosage & Administration

1 tablet once daily, preferably in the morning.

Contraindications

Thiazides and related diuretics should be avoided in refractory hypokalaemia, hyponatraemia and hypercalcaemia, symptomatic hyperuricaemia and Addison's disease.

Warning & Precautions

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.

Side effects

Side effects of Indapamide include headache, anorexia, gastric irritation,nausea, vomiting, constipation, diarrhoea etc.

Drug interaction

Other antihypertensive: Indapamide may add to or potentiate the action of other antihypertensive drugs. Norepinephrine: Indapamide like thiazides, may decrease arterial responsiveness to norepinephrine. Lithium: In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity.

Use in special groups

Use in pregnancy:Pregnancy Category B : Indapamide is a US FDA pregnancy category B drug. This means that it can be used during pregnancy.
Use in lactation: It is not known whether Indapamide is excreted in breast milk.

Packing

Xelix SR Tablet: Each box contains 30's tablets in blister pack.

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