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Gatifloxacin

Gatifloxacin is an 8-methoxyfluoroquinolone with a 3-methylpiperazinyl substituent at C-7 which shows antibacterial activity by inhibiting the bacterial enzyme DNA gyrase and topoisomerase IV.

Product Details

Presentation

Tag Sterile Eye Drops: Each ml contains Gatifloxacin Sesquihydrate INN equivalent to Gatifloxacin 3 mg.

Pharmacology

Gatifloxacin is an 8-methoxyfluoroquinolone with a 3-methylpiperazinyl substituent at C-7 which shows antibacterial activity by inhibiting the bacterial enzyme DNA gyrase and topoisomerase IV.

Indication

•Tag Sterile Eye Drops is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms:
Aerobic Gram-Positive Bacteria:
Corynebacterium propinquum
Staphylococcus aureus
Staphylococcus epidermidis
Streptococcus mitis
Streptococcus pneumoniae
Aerobic Gram-Negative Bacteria:
Haemophilus influenzae
•It is also indicated for the treatment of keratitis, blepharitis, pre- and post-operative treatment.

Dosage & Administration

For bacterial conjunctivitis and blepharitis:
Days 1 and 2: Instill 1 drop every two hours in the affected eye(s) while awake, up to 8 times daily.
Days 3 to 7: Instill 1 drop up to four times daily while awake.
For keratitis: Instill 1 drop every 15 minutes in the affected eye(s) for 4 hours, then 4 times daily upto 10 days.
For pre-operatively: Instill 1 drop 4 times/day for 2 days, and then 1 drop every 10 minutes before 1 hour of surgery.
For post-operatively: Instill 1 drop 4 times/day for 7 days.

Contraindications

Gatifloxacin 0.3% eye drops is contraindicated in patients with a history of hypersensitivity to Gatifloxacin, to other quinolones, or to any of the components in this medication.

Warning & Precautions

•Prolonged use with other anti-infectives may result in overgrowth of non-susceptible organisms, including fungi.
•Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.
•Avoid contaminating the applicator tip with material from the eye, fingers or other source.

Side effects

Reported side effects are conjunctival irritation, increased lacrimation, keratitis, and papillary conjunctivitis upon instillation. Other side effects are chemosis, conjunctival hemorrhage, dry eye, eye discharge, eye irritation, eye pain, eyelid edema, headache, red eye, reduced visual acuity and taste disturbance.

Use in special groups

Use in pregnancy: Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Gatifloxacin should be used during pregnancy only if the benefit justifies the potential risk to the fetus.
Use in lactation: It is not known whether Gatifloxacin is excreted in human milk. So, caution should be exercised when Gatifloxacin is administered to a nursing woman.

Packing

Tag Sterile Eye Drops: Each plastic dropper bottle contains 5 ml sterile eye drops.

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