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Nexol

Ambroxol

Ambroxol is a metabolite of bromhexine. It is an expectoration improver and mucolytic agent used in the treatment of acute and chronic disorders characterized by the production of excess or thick mucus. It causes the formation of qualitatively different mucus of lower viscosity by the mucus-secreting cells and thus leads to a liquefication of mucus in the lumen of the respiratory tract. Expectoration of mucus is facilitated and breathing is eased remarkably. Ambroxol also has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.

Product Details

Presentation

Nexol Syrup: Each 5 ml syrup contains Ambroxol hydrochloride BP 15 mg.
Nexol Paediatric Drops: Each ml pediatric drop contains Ambroxol hydrochloride BP 6 mg.

Pharmacology

Ambroxol is a metabolite of bromhexine. It is an expectoration improver and mucolytic agent used in the treatment of acute and chronic disorders characterized by the production of excess or thick mucus. It causes the formation of qualitatively different mucus of lower viscosity by the mucus-secreting cells and thus leads to a liquefication of mucus in the lumen of the respiratory tract. Expectoration of mucus is facilitated and breathing is eased remarkably. Ambroxol also has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.

Indication

Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis, Inflammatory disease of rhinopharyngeal tract (Laryngitis, Phryngitis, sinusitis and rhinitis) associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick expectoration, Bronchiectasis, Chronic pneumonia.

Dosage & Administration

Average daily dose (preferably after meal):
Nexol Paediatric Drops:
0 - 6 months old : 0.5 ml twice daily
6 - 12 months old : 1 ml twice daily
1 - 2 years old : 1.25 ml twice daily
Nexol Syrup:
2 -5 years old : 2.5 ml (1/2 teaspoonful) 2-3 times daily
5 - 10 years old : 5 ml (1 teaspoonful) 2-3 times daily
10 years old and adults: 10 ml (2 teaspoonful) 3 times daily

Contraindications

Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

Warning & Precautions

Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Caution should be taken in Patients with hepatic and renal insufficiency.

Side effects

Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema has been reported.

Drug interaction

Ambroxol should not be taken simultaneously with antitussives like Codeine because phlegm, which has been liquefied by Ambroxol might not be expectorated.

Use in special groups

Use in Pregnancy :
Although no evidence has been obtained (even at high dosage levels) of teratological activity administration is not recommended during the first trimester of pregnancy.
Use in Lactation :
Safety during lactation has not yet been established.

Packing

Nexol Syrup: Bottle contains 100 ml syrup.
Nexol Paediatric Drops: Bottle contains 15 ml pediatric drops

Other Products from
Bronchodilator & Antitussive
 
Salbutamol
Levosalbutamol
Theophylline
Doxophylline
Bromhexine
Dextromethorphan + Pseudoephedrine + Triprolidine
Montelukast
Ambroxol Hydrochloride

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