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Combipres

Combipres

Brimonidine + Timolol

Combipres Sterile Eye Drops is comprised of two components: Brimonidine Tartrate & Timolol Maleate. Brimonidine Tartrate is a selective alpha-2 adrenergic receptor agonist having a dual mechanism of action. It decreases aqueous humor production and increases nonpressure dependent uveoscleral outflow. Timolol Maleate is a ß-adrenergic receptor antagonist that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. It lowers IOP by reducing aqueous humor production. Therefore combination of both drugs gives a rapid onset of action, with peak ocular hypotensive effect seen within two hours of administration.

Product Details

Presentation

Combipres Sterile Eye Drops: Each ml contains Brimonidine Tartrate INN 2 mg and Timolol Maleate BP equivalent to Timolol 5 mg.

Pharmacology

Combipres Sterile Eye Drops is comprised of two components: Brimonidine Tartrate & Timolol Maleate. Brimonidine Tartrate is a selective alpha-2 adrenergic receptor agonist having a dual mechanism of action. It decreases aqueous humor production and increases nonpressure dependent uveoscleral outflow. Timolol Maleate is a ß-adrenergic receptor antagonist that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. It lowers IOP by reducing aqueous humor production. Therefore combination of both drugs gives a rapid onset of action, with peak ocular hypotensive effect seen within two hours of administration.

Indication

Combipres Sterile Eye Drops is indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

Dosage & Administration

Instill 1 drop in the affected eye(s) twice daily.

Contraindications

Contraindicated in patients with hypersensitivity to any component of this product. Also contraindicated in bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure and cardiogenic shock.

Warning & Precautions

Like other topically applied ophthalmic agents, it may be absorbed systemically. Due to the presence of Timolol, the same types of cardiovascular and pulmonary adverse reactions as seen with systemic beta-blockers may occur. Cautions should be exercised in treating patients with severe or unstable and uncontrolled cardiovascular or pulmonary diseases.

Side effects

Most common side effects are allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus and ocular burning or stinging.

Drug interaction

Specific drug interaction studies have not been conducted.

Use in special groups

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Combipres should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: Timolol has been detected in human milk but it is not known whether Brimonidine Tartrate is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Packing

Combipres Sterile Eye Drops: Each plastic dropper bottle contains 5 ml sterile eye drops.

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