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Alphaten

Alphaten

Brimonidine Tartrate

Alphaten is a relatively selective alpha-2 adrenergic receptor agonist and approximately 1000 times more selective for the alpha-2 adrenoreceptor than the alpha-1 adrenoreceptor.

Product Details

Presentation

Each ml contains Brimonidine Tartrate INN 2 mg.
Preservative: Sodium Perborate BP 0.01%.

Pharmacology

Alphaten is a relatively selective alpha-2 adrenergic receptor agonist and approximately 1000 times more selective for the alpha-2 adrenoreceptor than the alpha-1 adrenoreceptor.

Indication

Alphaten is effective for lowering intraocular pressure in patients with chronic open-angle glaucoma or ocular hypertension.

Dosage & Administration

The recommended dose is 1 drop into the affected eye(s) twice daily (doses taken approximately 12 hours apart).

Contraindications

This is contraindicated in patients with hypersensitivity to brimonidine tartrate or any component of this medication. This product is also contraindicated in patients receiving monoamine oxidase (MAO) inhibitor therapy & patients on antidepressants which affect noradrenergic transmission.

Warning & Precautions

Brimonidine should be used with caution in patients with known hypersensitivity to other alpha-adrenoreceptor agonists.

Side effects

The adverse effects reported with this drug may include headache; itching of eye; redness of eye or inner lining of eyelid; swelling of eyelid; tearing of eye.

Drug interaction

Brimonidine interacts with alpha-agonists that may reduce the pulse and blood pressure, CNS depressants e.g. sedatives which may give an additive or potentiating effect, tricyclic antidepressants which can affect the metabolism & uptake of circulating amines and blunt the hypotensive effect of systemic clonidine. But it is not known whether the concurrent use of these agents with this drug in humans can lead to resulting interference with the IOP lowering effect.

Use in special groups

Use in pregnancy:
There are no adequate and well-controlled studies of Brimonidine in pregnant women. Brimonidine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in lactation:
It is not known whether Brimonidine is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Use in children:
Safety and effectiveness in children below the age of 2 years have not been established.
Use in elderly patient:
No overall differences in safety or effectiveness have been observed between elderly and other adult patients.

Packing

Each plastic dropper bottle contains 5 ml sterile eye drops.

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