Optimox Tablet: Each film coated tablet contains Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 400 mg.
Moxifloxacin is a member of the fluoroquinolone class of antibacterial agents. It has broad spectrum of activity and antibacterial action. It exerts activity against a wide range of Gram-positive, Gram-negative, anaerobic and atypical bacteria including Mycoplasma pneumoniae. The bactericidal action results from the inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV which are required for bacterial DNA replication, transcription & repair.
Optimox is indicated for treating the following infections caused by susceptible bacteria. 1. Community acquired pneumonia 2. Exacerbation of chronic bronchitis 3. Sinusitis 4. Skin and soft tissue infections 5. Pelvic inflammatory disease 6. Complicated intra-abdominal infections 7. Hospital-acquired pneumonia 8. Infective endocarditis etc.
Dosage & Administration
The recommended dose of Optimox is 400 mg once daily. The duration of therapy depends on the type of infections. Community Acquired Pneumonia 400 mg once daily for 7-14 days, Exacerbation of chronic bronchitis 400 mg once daily for 5-10 days, Sinusitis 400 mg once daily for 7-10 days, Skin and soft tissue infections 400 mg once daily for 7-21 days, Pelvic inflammatory diseases 400 mg once daily for 14 days, Complicated intra-abdominal infections 400 mg once daily for 5-14 days, Hospital-acquired pneumonia 400 mg once daily for 7-8 days, Infective endocarditis 400 mg once daily for 28-42 days. No dosage adjustment is required in patients with renal or hepatic impairment.
Optimox is contraindicated in the patients with known hypersensitivity to Moxifloxacin or other quinolones.
Warning & Precautions
Moxifloxacin has been shown to prolong the QT interval in some patients. It should be avoided in patients with known prolongation, hypokalemia and with drugs that prolong the QT interval. It may cause increased risk of tendinitis and tendon rupture. It should be discontinued if pain or inflammation in a tendon occurs.
Most side effects reported with Moxifloxacin treatment are mild to moderate in nature and require no treatment. Most common adverse reactions are nausea, diarrhea, headache and dizziness.
Antacids, sucralfate, multivitamins and other products containing multivalent cations reduces the absorption of Moxifloxacin. Moxifloxacin should be administered 4 hours before or 8 hours after antacids, sucralfate, multivitamins and other products with multivalent cations. It may enhance anticoagulant effect of warfarin and proarrythmic effect of Class IA and Class III antiarrhythmics. So concomitant use of Moxifloxacin with them should be avoided. No clinically significant drug interactions of theophylline, digoxin, or glyburide have been observed with Moxifloxacin.
Use in special groups
Pregnancy: Pregnancy category C drug. Because no adequate or well-controlled studies have been conducted in pregnant women, Moxifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing mothers: Moxifloxacin may be excreted in the human breast milk. Because of the potential for serious adverse reactions in infants nursing from mothers taking Moxifloxacin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric patients: Safety and effectiveness in pediatric patients and adolescent less than 18 years of age have not been established.
Optimox Tablet(10's): Each box contains 10 tablets in alu-alu blister pack.