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Apuldon

Domperidone

Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Product Details

Presentation

Apuldon Tablet: Each tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.
Apuldon Suspension: Each 5 ml contains Domperidone BP 5 mg.
Apuldon Paediatric Drops: Each ml contains Domperidone BP 5 mg.
Apuldon-15 Suppository: Each suppository contains Domperidone BP 15 mg.
Apuldon-30 Suppository: Each suppository contains Domperidone BP 30 mg.

Pharmacology

Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Indication

1. Stimulation of gut mobility: Non-ulcer dyspepsia, esophageal reflux, reflux esophagitis & gastritis, diabetic gastroparesis.
2. Prevention and symptomatic relief from acute nausea & vomiting in adults from any cause but especially in cytotoxic therapy & radiotherapy, associated with migraine attacks (in combination with analgesics) and L-dopa and bromocriptine treatment for Parkinsonian patients.
3. Functional dyspepsia.

Dosage & Administration

The recommended oral dose for:
Adults: 10-20 mg every 4-8 hours daily.
Children (2-12 years): 0.2-0.4 mg/kg body weight (0.4-0.8ml paediatric drops/10 kg) every 4-8 hours daily.
Suppository: Adult and child body weight over 35 kg: 60 mg twice daily; child 15-35 kg (nausea and vomiting only): 30 mg twice daily.
Note: Both tablet & suspension should be taken 15-30 minutes before a meal. For acute nausea & vomiting maximum period of treatment is 12 weeks.

Contraindications

Patients with a known allergy to Domperidone or Domperidone Maleate or any inactive ingredient of the product.

Warning & Precautions

In case of children, treatment with Apuldon should be continued with caution because there may be increased risk of extra-pyramidal reactions in young children.

Side effects

Apuldon may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Drug interaction

Apuldon may reduce the hypoprolactinemic effect of bromocriptine. The effect of antimuscarinics & opioid analgesics may antagonize Apuldon on GI function.

Use in special groups

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Apuldon may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Packing

Apuldon Tablet: Each box contains 100 tablets in blister pack.
Apuldon Suspension: Each bottle contains 60 ml suspension.
Apuldon Paediatric Drops: Each bottle contains 15 ml drops.
Apuldon-15 Suppository: Each box contains 10 suppositories in PVC / PE strip pack.
Apuldon-30 Suppository: Each box contains 10 suppositories in PVC / PE strip pack.

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