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Acliz

Acliz

Meclizine

Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Meclizine has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours.

Product Details

Presentation

Acliz Tablet: Each chewable tablet contains Meclizine HCl USP 50 mg.

Pharmacology

Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Meclizine has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours.

Indication

Prevention and treatment of nausea, vomiting, motion sickness and vertigo.

Dosage & Administration

Nausea and vomiting: 25-50 mg once daily.
Motion sickness: Take an initial dose of 25 to 50 mg, 1 hour prior to travel. May repeat dose every 24 hours for the duration of the journey.Children: Age 6-12 years, 12.5 mg once daily. Age 2-6 years, 6.25 mg once daily.
Vertigo: 25 to 100 mg daily in divided doses.
Radiotherapy induced nausea and vomiting: 50 mg two to twelve hours prior to radiotherapy.

Contraindications

Hypersensitivity to meclizine.

Warning & Precautions

Hazardous tasks: May produce drowsiness; patients should observe caution while driving or performing other tasks requiring alertness.
Because of the anticholinergic action of this agents, use with caution and with appropriate monitoring in patients with glaucoma, obstructive disease of the GI or GU tract, and in elderly males with possible prostatic hypertrophy. These drugs may have a hypotensive action, which may be confusing or dangerous in postoperative patients.
May have additive effects with alcohol and other CNS depressants (eg. hypnotics, sedatives, tranquilizers, antianxiety agent); use with caution.

Side effects

Cardiovascular: Hypotension; palpitations; tachycardia.
CNS: Drowsiness, restlessness, excitation, nervousness, insomnia, euphoria, blurred vision, diplopia, vertigo, and tinnitus, auditory and visual hallucinations (particularly when dosage recommendations are exceeded.)
Dermatologic: Urticaria, rash
Gastrointestinal: Dry mouth; anorexia, nausea, vomiting, diarrhoea, constipation.
Urinary tract: Urinary frequency, difficult urination, and urinary retention.
Miscellaneous: Dry nose and throat.

Use in special groups

Use in pregnancy: Category B.Large scale human studies have not demonstrated adverse fatal effects. It has been demonstrated that, based on available data, Meclizine presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy.
Use in lactation: Meclizine may be excreated into breast milk. However problem in humans have not been documented.
Use in children: Meclizine can be given to children of 2 and above years of age.

Packing

Acliz Tablet: Each box contains 100's tablets in blister pack.

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