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Ametil

Ametil

Prochlorperazine

Prochlorperazine is a potent phenothiazine antipsychotic, derivative of the piperazine group, now largely used as an antiemetic and to treat vertigo. The effects of this drug is apparent at all levels of the nervous system. It antagonizes postsynaptic dopamine D1 receptor that activates adenylate cyclase and synthesis of cAMP. It also antagonizes D2 receptors which do not activate adenylate cyclase. It also inhinits pre- and post synaptic adrenoreceptors and also acetylcholine, serotonin and histamine receptors. These various pharacodynamic actions combine to produce not only antipsychotic, but also central antiemetic and sedative effects.

Product Details

Presentation

Ametil Tablet: Each tablet contains Prochlorperazine Maleate BP 5 mg.

Pharmacology

Prochlorperazine is a potent phenothiazine antipsychotic, derivative of the piperazine group, now largely used as an antiemetic and to treat vertigo. The effects of this drug is apparent at all levels of the nervous system. It antagonizes postsynaptic dopamine D1 receptor that activates adenylate cyclase and synthesis of cAMP. It also antagonizes D2 receptors which do not activate adenylate cyclase. It also inhinits pre- and post synaptic adrenoreceptors and also acetylcholine, serotonin and histamine receptors. These various pharacodynamic actions combine to produce not only antipsychotic, but also central antiemetic and sedative effects.

Indication

Severe nausea, vomiting, vertigo and other psychotic disorders.

Dosage & Administration

Nausea & vomiting: 5 to 10 mg two to three times daily. 20 mg at starting & 10 mg two hours later or as directed by physicians.
Vertigo and Meniere's syndrome: 5 mg thrice and max. 30 mg daily. After several weeks dosage may be reduced to 5-10 mg daily or as directed by physicians.
Anxiety: 15-20 mg daily in divided doses initially but this may be increased to a max. 40 mg daily or as directed by physicians.
Schizophrenia and other psychotic disorders: 75 to 100 mg daily, but patients; response varies widely in response and the dosage schedule for Ametil is initially 12.5 mg twice daily for 7 days, the dose per day may be increased at four to seven days intervals until a satisfactory response is obtained. After some weeks, the effective dosage can be reduced.
Children: For the treatment of nausea and vomiting, the dose is 0.25 mg/kg body weight two to three times a day or as directed.

Contraindications

Hypersensitivity, jaundice, CNS depression and in cardiovascular diseases.

Side effects

Drowsiness, dryness of mouth, mild skin rashes, neuromuscular effects, blurred vission, convulsion, difficulty in breathing may occur rarely

Use in special groups

Use in pregnancy: Safety of this drug in pregnancy has not been established. Pregnant mothers should use this drug only in case of severe nausea & vomiting with recognition of the potential risk.
Use in lactation: Prochlorperazine releases in breast milk. So lactating mothers should not use this drug.

Packing

Ametil Tablet: Each box contains 500's tablets in strip pack.

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