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Tenocard

Tenocard

Atenolol

Atenolol is a cardioselective, beta-1 adrenergic blocking agent, preferably in the heart.

The principal physiologic action of Atenolol is to competitively block adrenergic receptors within the myocardium and within vascular smooth muscle. Atenolol also slows conduction in the atrioventricular (AV) node.

Atenolol is effective for at least 24 hours after a single oral dose. Only about 50-60% of an oral dose of Atenolol is absorbed from gastrointestinal tract. Approximately 5% of Atenolol is bound to plasma protein and is well distributed in most tissues and fluids except brain and CSF. Patients with normal renal function, Atenolol has pasma half-life of 6 to 7 hours.

Product Details

Presentation

Tenocard Tablet: Each tablet contains Atenolol BP 50 mg.

Pharmacology

Atenolol is a cardioselective, beta-1 adrenergic blocking agent, preferably in the heart.

The principal physiologic action of Atenolol is to competitively block adrenergic receptors within the myocardium and within vascular smooth muscle. Atenolol also slows conduction in the atrioventricular (AV) node.

Atenolol is effective for at least 24 hours after a single oral dose. Only about 50-60% of an oral dose of Atenolol is absorbed from gastrointestinal tract. Approximately 5% of Atenolol is bound to plasma protein and is well distributed in most tissues and fluids except brain and CSF. Patients with normal renal function, Atenolol has pasma half-life of 6 to 7 hours.

Indication

1. Management of hypertension.
2. Management of angina pectoris.
3. Management of cardiac disarhythmias.
4. Myocardial infarction: early intervention in the acute phase.

Dosage & Administration

Usual recommended dose in hypertension is 25-50 mg daily, in angina is 100 mg daily in 1 or 2 doses and in arrhythmias is 50-100 mg daily.

Contraindications

Atenolol is contraindicated in patients with asthma, heart failure, second or third degree heart block.

Warning & Precautions

Avoid abrupt withdrawl in angina. Reduce oral dose of Atenolol in liver disease and reduce initial dose in renal impairment. Patients who have tendency towards obstructive airways disease should be treated with caution.

Side effects

Bradycardia, heart failure, peripheral vasoconstriction and gastrointestinal disturbances may occur.

Use in special groups

Use in pregnancy: Atenolol has been effectively used only under close supervision for the treatment of pregnancy-associated hypertension. There was no evidence of foetal abnormalities although atenolol was used after 20 weeks of gestation.
Use in lactation: Atenolol crosses the placental barrier and appears in cord blood. Approximately three fold accumulation of Atenolol occurs in breast milk. However, apparently no harmful effects were seen in the newborn or the breast fed babies.

Packing

Tenocard Tablet: Each box contains 100's tablets in blister pack.

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