Our Products

Product details Products Home
Lodipin

Lodipin

Amlodipine besilate

Amlodipine is a dihydropyridine calcium antagonist, with a long duration of action, used for the treatment of hypertension and angina pectoris.

Product Details

Presentation

Lodipin 5 Tablet: Each tablet contains Amlodipine besilate BP equivalent to Amlodipine 5 mg.

Pharmacology

Amlodipine is a dihydropyridine calcium antagonist, with a long duration of action, used for the treatment of hypertension and angina pectoris.

Indication

1. Hypertension: Lodipin is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
2. Stable angina: Lodipin is indicated for the treatment of stable angina. It may be used alone or in combination with other antianginal agents.
3. Vasospastic angina: Lodipin is indicated for the treatment of confirmed or suspected vasospastic angina. It may be used as monotherapy or in combination with other antianginal agents.

Dosage & Administration

Hypertension or angina: Initially 5 mg once daily; max 10 mg once daily.

Contraindications

Amlodipine is contraindicated in patients with known hypersensitivity to Amlodipine.

Warning & Precautions

General: Since the vasodilatation induced by Amlodipine is gradual in onset, acute hypertension has rarely been reported after oral administration of Amlodipine. Nonetheless, caution should be exercised when administering Amlodipine as with any other peripheral vasodilator particularly in patients with severe heart failure.
Use in patients with congestive heart failure: Although haemodynamic studies and a controlled trial in class II-III heart failure patients have shown that Amlodipine did not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection factor and clinical symptomatology in general, all calcium channel blockers should be used with caution in patients with heart failure.
Beta-blocker withdrawal: Amlodipine gives no protection against the danger of abrupt beta-blocker withdrawal, any such withdrawal should be gradual reduction of the dose of beta-blocker.
Hepatic failure: Since Amlodipine is extensively metabolized by the liver, so caution should be exercised when administering Amlodipine to patients with hepatic impairment.

Side effects

Peripheral edema may occasionally be severe but is fully reversible. And as with other calcium antagonist drugs, peripheral edema and skin erythema occur in a proportion of patients (5-10%) and facial flushing in 2.5% of patients. Complaints of fatigue was also reported more frequently than in placebo-treated patients. There is evidence that these effects are more common in patients treated with doses greater that 10 mg daily. Clinical experience with Amlodipine is still relatively limited and as this increases, a more reliable assessment of toxicity and side effects can be provided.

Drug interaction

Digoxin: Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been documented in controlled clinical study.
Cimetidine: An unpublished clinical study indicated no interaction between Amlodipine and Cimetidine in healthy volunteers.
Warfarin: An unpublished study in healthy volunteers indicates that Amlodipine did not significantly alter the effect of Warfarin on prothrombin time.
Food: Food does not alter the rate or extent of absorption of Amlodipine.

Packing

Lodipin 5 Tablet: Each box contains 60's tablets in blister pack.

Other Products from
Cardiovascular
 
Digoxin
Bisoprolol Hemifumarate
Bisoprolol Fumarate + Hydrochlorothiazide
Aspirin + Clopidogrel
Metoprolol
Amlodipine Besilate + Olmesartan Medoxomil
Spironolactone + Furosemide
Candesartan
Candesartan + Hydrochlorothiazide
Enoxaparin Sodium
Isosorbide -5-Mononitrate
Lacidipine
Amlodipine + Atenolol
Amlodipine
Trimetazidine
Nitroglycerin
Diluted Nitroglycerin
Losartan
Losartan + Hydrochlorothiazide
Olmesartan Medoxomil
Ramipril
Atenolol
Indapamide

© 2017. Aristopharma Ltd. All rights reserved.
Site by DIGITA iNTERACTIVE

HOME | PRODUCTS | FACILITIES | GLOBAL PRESENCE | NEWS | ABOUT US | CONTACT | CAREER

Webmail
Bookmark and Share