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Glucozid

Glucozid

Gliclazide

Gliclazide is a second-generation oral hypoglycemic sulfonylurea, which stimulates the release of insulin from pancreatic beta cells by facilitating Ca++ transport across the beta-cell membrane and decreases hepatic glucose output.

Product Details

Presentation

Glucozid Tablet: Each Glucozid tablet contains Gliclazide BP 80 mg.

Pharmacology

Gliclazide is a second-generation oral hypoglycemic sulfonylurea, which stimulates the release of insulin from pancreatic beta cells by facilitating Ca++ transport across the beta-cell membrane and decreases hepatic glucose output.

Indication

Glucozid (Gliclazide) is indicated for control of blood glucose in patients with non-insulin dependent diabetes mellitus (Type-II, maturity onset diabetes mellitus) whose hyperglycemia cannot be controlled by diet alone.

Dosage & Administration

Initially, 40-80 mg daily adjusted according to response, up to 160 mg as a single dose with breakfast; higher doses divided; Max. 320 mg daily.

Contraindications

Hypersensitivity to sulfonylurea, diabetes complicated by ketoacidosis with coma, as a sole therapy of insulin-dependent (Type-1) diabetes mellitus, diabetes when complicated by pregnancy & breast-feeding.

Warning & Precautions

Care should be exercised in patients with hepatic and/or renal impairment. In long term clinical trials patients with renal insufficiency have been treated satisfactory using Gliclazide at reduced doses.

Side effects

Hypoglycemia may occur in concurrent conditions such as hepatic & renal diseases, alcohol intoxication and adrenal & pituitary insufficiency.

Gastro-intestinal disturbances such as vomiting, diarrhoea & cinstipation.
Allergic skin reactions including rash, pruritus, and erythema, urticarias have been reported. These may be transient and may disappear despite continued use of the drug.

Drug interaction

Androgens, anticoagulants, chloramphenicol, fluconazole, miconazole, histamine H2 antagonists, MAO inhibitors, phenylbutazone, probenecid, salicylates, sulfonamides, and tricyclic antidepressants may enhance the hypoglycemic effect of Glucozid.
Beta-blockers, rifampicin and thiazide diuretics, thyroid hormones, laxatives and oral contraceptives may decrease the hypoglycemic effect of Glucozid.

Use in special groups

In pregnancy & Lactation: Gliclazide should not be used.

Packing

Glucozid Tablet: Each box contains 50's tablets in blister pack.

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