Aristopharma Ltd

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Combipres (Brimonidine + Timolol)

Therapeutic Group : Antiglaucoma

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Combipres Sterile Eye Drops is comprised of two components: Brimonidine Tartrate & Timolol Maleate. Brimonidine Tartrate is a selective alpha-2 adrenergic receptor agonist having a dual mechanism of action. It decreases aqueous humor production and increases non-pressure dependent uveoscleral outflow. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. It lowers IOP by reducing aqueous humor production. Therefore, combination of both drugs gives a rapid onset of action, with peak ocular hypotensive effect seen within two hours of administration.