Aristopharma Ltd

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Arotrix (Permethrin)

Therapeutic Group : Antiscabies

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The principal physiological action in insects exposed to Permethrin is induction of electrochemical abnormalities acrossthe membrane of excitable cells, leading to sensory hyperexcitability, incoordination and prostration. It assumes that the mode of action against mites is similar. Topical route is the only approved route of administration of Permethrin. Some presystemic metabolism occurs in the skin after application. Less than 0.5% of applied Permethrin is absorbed during the first 48 hours. Absorbed Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.