Indapamide is a diuretic antihypertensive. It appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. It has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Xelix SR Tablet: Each sustained release tablet contains Indapamide USP 1.5 mg
•Essential hypertension
•Salt and fluid retention associated with congestive heart failure
1 tablet once daily, preferably in the morning.
Thiazides and related diuretics should be avoided in refractory hypokalaemia, hyponatraemia and hypercalcaemia, symptomatic hyperuricaemia and Addison's disease.
Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.
Side effects of Indapamide include headache, anorexia, gastric irritation,nausea, vomiting, constipation, diarrhoea etc.
Other antihypertensive: Indapamide may add to or potentiate the action of other antihypertensive drugs. Norepinephrine: Indapamide like thiazides, may decrease arterial responsiveness to norepinephrine. Lithium: In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity.
Use in pregnancy:Pregnancy Category B : Indapamide is a US FDA pregnancy category B drug. This means that it can be used during pregnancy.
Use in lactation: It is not known whether Indapamide is excreted in breast milk.
Xelix SR Tablet: Each box contains 30's tablets in blister pack.
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