Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.


    Apuldon Tablet: Each film-coated tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.
    Apuldon Suspension: Each 5 ml contains Domperidone BP 5 mg.
    Apuldon Paediatric Drops: Each ml contains Domperidone BP 5 mg.


    1. Stimulation of gut mobility: Non-ulcer dyspepsia, esophageal reflux, reflux esophagitis & gastritis, diabetic gastroparesis.
    2. Prevention and symptomatic relief from acute nausea & vomiting in adults from any cause but especially in cytotoxic therapy & radiotherapy, associated with migraine attacks (in combination with analgesics) and L-dopa and bromocriptine treatment for Parkinsonian patients.
    3. Functional dyspepsia.

Dosage & Administration

    The recommended oral dose for:
    Adults: 10-20 mg every 4-8 hours daily.
    Children (2-12 years): 0.2-0.4 mg/kg body weight (0.4-0.8ml paediatric drops/10 kg) every 4-8 hours daily.


    Patients with a known allergy to Domperidone or Domperidone Maleate or any inactive ingredient of the product.

Warning & Precautions

    In case of children, treatment with Apuldon should be continued with caution because there may be increased risk of extra-pyramidal reactions in young children.

Side effects

    Apuldon may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness & reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash & itching.

Drug interaction

    Apuldon may reduce the hypoprolactinemic effect of bromocriptine. The effect of antimuscarinics & opioid analgesics may antagonize Apuldon on GI function.

Use in special groups

    Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

    Use in lactation: Apuldon may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.


    Apuldon Tablet: Each box contains 100 tablets in blister pack.
    Apuldon Suspension: Each bottle contains 60 ml suspension.
    Apuldon Paediatric Drops: Each bottle contains 15 ml drops.