Voriconazole is an azole antifungal drug. It inhibits the fungal cytochrome P-450 mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlate with the subsequent loss of ergosterol in the fungal cell wall and may be responsible for the antifungal activity of voriconazole.
Caspa 50 Tablet: Each film coated tablet contains Voriconazole USP 50 mg.
Caspa 200 Tablet: Each film coated tablet contains Voriconazole USP 200 mg.
Caspa is indicated for the treatment of adults and pediatric patients 2 years of age and older with:
* Invasive aspergillosis
* Candidemia in non-neutropenics and other deep tissue Candida infections
* Esophageal candidiasis
* Serious fungal infections caused by Scedosporium apiospermum and Fusarium species including Fusarium solani, in patients intolerant of, or refractory to, other therapy.
Caspa tablets or oral suspension to be taken at least one hour before or after a meal.
Dosage in adults
|Loading (Day-1)||Maintenance (From Day-2)|
|Invasive Aspergillosis||400 mg every 12 hours||200 mg every 12 hours for 11 weeks|
|Serious Fungal infections like Scedosporiosis and Fusariosis|
|Candidemia (non-neutropenic) and other deep tissue Candida infections||200 mg every 12 hours for at least 14 days after resolution of symptoms|
|Esophageal Candidiasis||200 mg every 12 hours for a minimum 14 days and for at least7 days after the resolution of sign & symptoms|
The most common side effects may include visual disturbances, fever, nausea, rash, vomiting, chills, headache, liver function test abnormal, tachycardia, hallucinations, pyrexia, epistaxis, abdominal pain, diarrhea, hypokalemia, cough, thrombocytopenia, peripheral edema, hyperglycemia, dyspnea, hypocalcemia, hypophosphatemia, LFT abnormal, mucosal inflammation, photophobia, abdominal distention, constipation, dizziness, hemoptysis, hypoalbuminemia, hypomagnesemia, renal impairment, upper respiratory tract infection etc.
Caspa 50 Tablet: Each box contains 12's tablets in alu-alu blister pack.
Caspa 200 Tablet: Each box contains 10's tablets in alu-alu blister pack.
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