Fluticasone Furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. Like other corticosteroids Fluticasone Furoate is found
to have a wide range of actions on multiple cell types.
Fluticasone Furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. Like other corticosteroids Fluticasone Furoate is found
to have a wide range of actions on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation.
Flutica Nasal Spray: Each metered dose spray contains Fluticasone Furoate INN 27.5 mcg.
Flutica Nasal Spray is indicated for the treatment of symptoms of seasonal and perennial allergic rhinitis in adults and children above 2 years and for the prevention of recurrence of nasal polyps following surgical removal.
For intranasal use only.
Adults and adolescents (12 years and over)
The recommended starting dosage is 2 sprays in each nostril once daily. Once adequate control of symptoms is achieved, dose reduction to one spray in each nostril once daily can be effective for maintenance.
Children (2 to 11 years of age)
The recommended starting dose is 1 spray in each nostril once daily.
Fluticasone Furoate is contraindicated for the patients who have hypersensitivity to any components of this preparation.
Patients taking Fluticasone Furoate nasal spray should be periodically monitored for signs of adverse effects on the nasal mucosa such as epistaxis, nasal ulceration and impaired wound healing. Avoid using the drug in patients with recent nasal ulcers, nasal surgery, or nasal trauma. Closely monitor patients with a history of increased intraocular pressure, glaucoma and hypersensitivity reactions (including anaphylaxis, angioedema, rash, and urticaria). Besides, potential worsening of existing fungal, bacterial, viral, or parasitic infections or ocular herpes simplex, hypercorticism and growth retardation may occur after the administration of Fluticasone Furoate nasal spray.
The most common side effects are headache, epistaxis, pharyngolaryngeal pain, nasal ulceration, back pain, pyrexia, and cough.
Potent inhibitors of cytochrome P450 3A4 (CYP3A4) may increase exposure to Fluticasone Furoate. Coadministration of ritonavir is not recommended. Use
caution with coadministration of other potent CYP3A4 inhibitors, such as ketoconazole.
Use in pregnancy: Pregnancy category C. Fluticasone Furoate nasal spray should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus.
Use in lactation: It is not known whether Fluticasone Furoate is excreted in human breast milk. Caution should be exercised when Fluticasone Furoate is administered to a nursing woman.
Geriatric use: In general, dose selection for the elderly patient should be cautious, keeping in mind the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Use in hepatic impairment: Use Fluticasone Furoate with caution in patients with severe hepatic impairment.
Use in renal impairment: No dosage adjustment is required in patients with renal impairment.
Flutica Nasal Spray: Each bottle contains Fluticasone Furoate aqueous suspension for 120 metered sprays
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