Description

Trimetazidine Hydrochloride is the new twice-daily formulation of the first 3- keto acyl CoA thiolase inhibitor (KAT), a metabolic anti-ischemic agent with proven benefits for all coronary patients. Trimetazidine inhibits fatty acid pathway by inhibiting 3-ketoacylCoA thiolase enzyme and transfers oxygen to glucose pathway.Since glucose pathway is more efficient in producing energy, the same oxygen produces more energy and makes the heat more active. Moreover, the aerobic oxidation of glucose stops production of lactic acid, which prevents angina pectoris.

Presentation

    Metacard MR Tablet: Each modified release tablet contains Trimetazidine Hydrochloride BP 35 mg.

Indications

    Metacard MR Tablet is a metabolic treatment for ischaemic heart disease. It can be used at all stages of angina pectoris and in post myocardial infarction. Metacard MR therapy has also demonstrated beneficial effects when administered during bypass surgery.

Dosage & Administration

    One tablet at mealtimes in the morning and evening.

Contrainidications

    Trimetazidine is contraindicated in-patients with a known hypersensitivity to its components.

Warning & Precautions

Side effects

    Trimetazidine is safe and well tolerated. Rare cases of gastrointestinal disorders, nausea & vomiting have been reported.

Drug interaction

    No drug interactions so far have been reported. In particular, no interactions have been reported with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidaemic agents or digitalis preparation.

Use in special groups

    Use in Pregnancy: Studies in animals have not demonstrated teratogenic effect. However, in the absence of clinical data and for safety reasons, prescription should be avoided during pregnancy.
    Use in Lactation: In the absence of data, breastfeeding is not recommended during treatment.

Packing

    Metacard MR Tablet: Each box contains 70's tablets in blister pack.