Ambroxol is a metabolite of bromhexine. It is an expectoration improver and mucolytic agent used in the treatment of acute and chronic disorders characterized by the production of excess or thick mucus. It causes the formation of qualitatively different mucus of lower viscosity by the mucus-secreting cells and thus leads to a liquefication of mucus in the lumen of the respiratory tract. Expectoration of mucus is facilitated and breathing is eased remarkably. Ambroxol also has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.
Nexol Syrup: Each 5 ml syrup contains Ambroxol Hydrochloride BP 15 mg.
Nexol Paediatric Drops: Each ml pediatric drop contains Ambroxol Hydrochloride BP 6 mg.
Average daily dose (preferably after meal):
2 -5 years old : 2.5 ml (1/2 teaspoonful) 2-3 times daily
5 - 10 years old : 5 ml (1 teaspoonful) 2-3 times daily
10 years old and adults: 10 ml (2 teaspoonfuls) 3 times daily
Nexol Paediatric Drops:
0 - 6 months old : 0.5 ml twice daily
6 - 12 months old : 1 ml twice daily
1 - 2 years old : 1.25 ml twice daily
Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.
Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Caution should be taken in Patients with hepatic and renal insufficiency.
Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema has been reported.
Ambroxol should not be taken simultaneously with antitussives like Codeine because phlegm, which has been liquefied by Ambroxol might not be expectorated.
Use in Pregnancy:
Although no evidence has been obtained (even at high dosage levels) of teratological activity administration is not recommended during the first trimester of pregnancy.
Use in Lactation:
Safety during lactation has not yet been established.
Nexol Syrup: Bottle contains 100 ml syrup.
Nexol Paediatric Drops: Bottle contains 15 ml pediatric drops.
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