Prednisolone is a corticosteroid that suppresses the inflammation. On the other hand neomycin sulfate and polymyxin B sulfate are active against a broad spectrum of microorganisms such as Staphylococcus aureus, Escherichia coli, Hemophilus influenza, Klebsiella, Enterobacter, Neisseria and Pseudomonas aeruginosa. Combination of these three drugs is highly effective in the treatment of inflammation associated with ocular infection.
Polyforte Sterile Ophthalmic Suspension: Each ml contains Prednisolone Acetate USP 5 mg, Neomycin Sulfate BP equivalent to Neomycin base 3.5 mg & Polymyxin B Sulfate BP 10000 IU.
Polyforte is indicated for steroid-responsive inflammatory ocular conditions where bacterial infection or a risk of bacterial ocular infection exists.
Instill 1-2 drops on eye every 3 or 4 hours, or more frequently as required. Acute infections may require administration every 30 minutes, with frequency of administration reduced as the infection is brought under control.
To treat the lids: Instill 1-2 drops in the eye every 3 to 4 hours, close the eye and rub the excess on the lids and lid margins.
This combination is contraindicated in viral diseases of the cornea and conjunctiva and mycobacterial infection of the eye.
This combination should be used with caution in patients with known hypersensitivity to the components of this preparation.
Some of the rare side effects are itching, swelling, and elevation of intraocular pressure (IOP).
Although systemic effects are extremely uncommon, there have been rare occurrences of systemic hypercorticoidism after use of topical steroids.
No drug-drug interaction is reported for the topical administration of this preparation.
Use in pregnancy: There are no adequate and well-controlled studies of combination in pregnant women. The combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in lactation: This combination is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Pediatric use: Safety and effectiveness in pediatric patients have not been established.
Geriatric use: No overall differences in safety or effectiveness have been observed between elderly and other adult patients.
Polyforte Sterile Ophthalmic Suspension: Each plastic dropper bottle contains 5 ml sterile ophthalmic suspension
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