Scabinil (Spinosad 0.9%) is a targeted topical therapy designed to treat scabies and head lice infestations in adults and children. It causes neuronal hyperexcitation in mites and lice, leading to paralysis and death. Scabinil provides a convenient, single-application option with minimal systemic absorption and a favorable safety profile.
Scabinil is a topical suspension containing Spinosad 0.9% w/w, derived from the fermentation of the soil bacterium Saccharopolyspora spinosa. It functions by binding to nicotinic acetylcholine receptors in the insect nervous system, triggering involuntary muscle contractions, tremors, paralysis, and ultimate death of mites, lice, and their eggs. Designed for topical administration, Scabinil demonstrates negligible systemic absorption through intact human skin, ensuring localized action with minimal side effects. It is indicated for treating scabies in patients 4 years and older, as well as head lice in patients 6 months and older.
Scabinil Topical Suspension: Each gm of topical suspension contains Spinosad INN 9 mg.
Scabies Infestations: Scabinil Topical Suspension is a scabicide indicated for the topical treatment of scabies infestations in adult and paediatric patients 4 years of age and older.
Head Lice Infestations: Scabinil Topical Suspension is a pediculicide indicated for the topical treatment of head lice infestations in adult and paediatric patients 6 months of age and older.
For topical use only. Not for oral, ophthalmic, or intravaginal use.
Treatment of Scabies Infestations: • The bottle should be shaken well before use • The suspension should be thoroughly rubbed into the entire body from the neck down to the soles of the feet • Patients with balding scalps should also apply the suspension to the scalp, hairline, temples, and forehead. • Sufficient time should be allowed for the suspension to absorb into the skin and dry for 10 minutes before dressing • Bathing should be avoided for at least 6 hours after application.
Treatment of Head Lice Infestations: • The bottle should be shaken well before use • The suspension should be applied thoroughly so that the scalp is completely covered. Then the medication should be applied to dry hair • After 10 minutes, the hair should be rinsed with warm water • If live lice are observed 7 days after the first treatment, the treatment should be repeated or as directed by the physician.
No information is available.
Benzyl alcohol can cause reactions. Not recommended in infants below the age of 6 months; potential for increased systemic absorption.
Most common adverse reactions:
• Scabies treatment (>1%) are application site irritation and dry skin.
• Lice treatment (>1%) are application site erythema and ocular erythema.
No information is available.
USE IN PREGNANCY & LACTATION
Pregnancy: Pregnancy category B
Lactation: Breastfeeding is not expected to result in the exposure of the child to Spinosad. Breastfeeding women should remove Spinosad Topical Suspension from the breast with soap and water before breastfeeding.
USE IN CHILDREN & ADOLESCENTS
Scabies Infestation: The safety and effectiveness of Spinosad Topical Suspension have not been established in pediatric patients less than 4 years of age with scabies infestation.
Head Lice Infestation: The safety and effectiveness of Spinosad Topical Suspension for the topical treatment of head lice infestation have been established in pediatric patients 6 months of age and older.
Scabinil Topical Suspension: Each bottle contains 60 ml topical suspension.
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