Silvadazin (Silver sulfadiazine) has broad antimicrobial activity. It is bactericidal for many Gram-negative and Gram-positive bacteria as well as being effective against yeast. After application of silver sulfadiazine cream onto the burn wound surface the compound acts a reservoir of silver ions. Silver ion exerts a bactericidal effect on bateria. Silver penetrates into cell of bacteria and binds to DNA, thereby inhibiting replications.
Silvadazin Cream: Each gram cream contains Silver Sulfadiazine USP 10 mg.
Prophylaxis and treatment of infection in burn wounds; as an adjunct to short-term treatment of infection in leg ulcers and pressure sore; as an adjunct to prophylaxis of infection in skin graft donor sites and extensive abrasions; for conservative management of finger-tip injuries.
The burn wound should be cleanded and Silvadazin applied over all the affected areas to a depth of 3 to 5 mm. One technique is to apply the cream with a sterile gloved hand and / or sterile nonmetallic spatula. Where necessary, the cream should be reapplied to any area from which it has been removed by patients activity. The cream should be reapplied at least every 24 hours.
Allergic reactions including burning, itching and rashes; neutropenia reported.
Pregnancy and breast-feeding; sensitivity to sulphonamides; not recommended for neonates.
Silvadazin Cream: Each tube contains 25g cream.
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