Combipres Eye Drops is comprised of two components: Brimonidine Tartrate & Timolol Maleate. Brimonidine Tartrate is a selective alpha-2 adrenergic receptor agonist having a dual mechanism of action. It decreases aqueous humor production and increases non-pressure dependent uveoscleral outflow. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. It lowers IOP by reducing aqueous humor production. Therefore, combination of both drugs gives a rapid onset of action, with peak ocular hypotensive effect seen within two hours of administration.



    Combipres Eye Drops is indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

Dosage & Administration

    Instill 1 drop in the affected eye(s) twice daily.


    Contraindicated in patients with hypersensitivity to any component of this product. Also contraindicated in bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure and cardiogenic shock.

Warning & Precautions

    Like other topically applied ophthalmic agents, it may be absorbed systemically. Due to the presence of Timolol, the same types of cardiovascular and pulmonary adverse reactions as seen with systemic beta-blockers may occur. Cautions should be exercised in treating patients with severe or unstable and uncontrolled cardiovascular or pulmonary diseases.

Side effects

    Most common side effects are allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus and ocular burning or stinging.

Drug interaction

    Specific drug interaction studies have not been conducted.

Use in special groups

    Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Combipres should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

    Use in lactation: Timolol has been detected in human milk but it is not known whether Brimonidine Tartrate is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

    Use in children: Safety and effectiveness in children below the age of 2 years have not been established.

    Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients. 


    Combipres Eye Drops: Each LDPE dropper bottle contains 5 ml sterile eye drops.