Fluconazole is fungistatic in action. It inhibits cytochrome P-450 14-alfa demethylase in susceptible fungi which leads to accumulation of lanosterol and decreased concentration of ergosterol thereby altering cellular membrane resulting in increased membrane permeability, leakage of essential elements and impaired uptake of precursor molecules to DNA.
Diflu Sterile Eye Drops: Each ml contains Fluconazole USP 3 mg
Diflu Sterile Eye Drops is indicated for the treatment of fungal corneal ulcers/keratitis.
Instill 1drop to be instilled into the affected eye(s) 5 times daily.
The drug is contraindicated in patients with hypersensitivity to azoles. Side effects: The drug is generally well tolerated. Eosinophillia has been reported in some patients.
Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than C. albicans.
Use in pregnancy: Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Fluconazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in lactation: Nursing mother should not be given as the drug is excreted in breast milk in concentration similar to plasma.
Use in children: Safety and efficacy of fluconazole in children younger than 13 years have not been established.
Diflu Sterile Eye Drops: Each plastic dropper bottle contains 5 ml sterile eye drops.
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