Natamycin exerts its antifungal activity by destroying the fungal cell membrane
Each ml contains Natamycin USP 50 mg.
N-Mycin sterile ophthalmic suspension is indicated for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by susceptible organisms including Fusarium solani.
For fungal keratitis: The preferred initial dosage is 1 drop instilled in the conjunctival sac (s) at 1-2 hours intervals. The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is a resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated.
For fungal blepharitis & conjunctivitis: A less frequent initial dosage, 1 drop 4-6 times daily may be sufficient.
Natamycin sterile ophthalmic suspension is contraindicated in individuals with a known hypersensitivity to any of its components.
For topical eye use only. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to natamycin.
Local irritation, conjunctival chemosis, hyperemia, etc.
Pregnancy: Category C: N-Mycin sterile ophthalmic suspension should be given to a pregnant woman only if clearly needed.
Use in Nursing Mothers: It is not known whether this drug is excreted in human milk. Caution should be exercised when natamycin is administered to a nursing mother.
Pediatric use: Safety and effectiveness in paediatric patients have not been established.
N-Mycin Sterile Ophthalmic Suspension: Each plastic dropper bottle contains 5 ml ophthalmic suspension.
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