Sodium Fusidate, an antibiotic derived from Fusidium coccineum, exerts powerful activity against a number of gram-positive organisms. Staphylococci, including the strains resistant to penicillin or other antibiotics, are particularly susceptible to Fusidate. The therapeutic efficacy of topically applied Fusidate is due partly to the pronounced antibacterial activity of Fusidate against the organisms responsible for skin infection and partly to the unique ability of this antibiotic to penetrate intact skin. Fusidic Acid is an anti-microbial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with the translocation step by stabilizing the ribosome-guanosine dephosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosome and thereafter stops transfer of additional amino acids to the growing polypeptide.
Fusidate Ointment: Each gram ointment contains Sodium Fusidate (Micronised) BP 20 mg.
Fusidate Ointment is indicated for treatment of skin infections caused by Staphylococci, Streptococci, Corynebacterium minutissimum and other Fusidate sensitive organisms. The most important indications being: impetigo, boils, abscess, varicose ulcers, skin grafts, hidradenitis, infected wounds, sycosis barbae, paronychia, folliculitis, carbuncles and erythrasma.
Fusidate Ointment is applied to the affected areas 2 to 3 times daily, generally for a period of 7 days. It can be used with or without a covering dressing. Caution should be observed when applying Fusidate Ointment near the eye region as this preparation may cause irritation if it gets into the eye. No special dosage modifications or special precautions are required for children.
Known hypersensitivity to Fusidic acid, severe hepatic failure.
Fusidate Ointment is remarkably well tolerated, and there is an extremely low frequency of hypersensitivity reactions.
Fusidate Ointment: Each tube contains 20 g ointment.
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