Fusidate H cream combines the potent topical antibacterial action of Fusidic Acid with the anti-inflammatory & anti-pruritic effect of Hydrocortisone Acetate. When applied topically, Fusidic Acid is effective against Staphylococci, Streptococci, Corynebacteria, Neisseria and certain Clostridia & Bacteroides. Fusidic Acid is an antimicrobial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with translocation step by stabillizing the ribosome-guanosine di-phosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosom and thereafter stops transfer of additional amino acids to the growing polypeptide. Hydrocortisone is, in human, the naturally occurring principal glucocorticosteroid. In pharmaceutical doses, its main action is to reduce the response of the skin to injury (i.e. anti-inflammatory). It also has immunosuppressant & anti-mitotic actions.



    Fusidate H Cream: Each gram cream contains Fusidic Acid BP 20 mg & Hydrocortisone Acetate BP 10 mg.


    • Primary irritant dermatitis.
    • Contact allergic dermatitis.
    • Eczema-atopic; infantile; discoid; stasis.
    • Seborrhoeic dermatitis.
    • Lichen simplex & pruritus ani.
    • Flexural psoriasis.

Dosage & Administration

    Fusidate-H cream should be applied in a thin smear to the rash 2-3 times daily, massaged gently into the skin generally for a period of 7 days to the affected area. As the skin rash improves, the frequency of application should be gradually reduced. As topical steroids exhibit tachyphytaxis, it may be better to omit therapy for several days severy fortnight.


    •Known hypersensitivity to any of the components.
    •Severe hepatic failure.
    •lnfection-bacterial, viral, fungal, skin infection.
    •Ulcers (delayed wound healing).
    •Infants under 1 year.

Warning & Precautions

Side effects

    Hypersensitivity has rarely encountered. As with other topical steroids, prolonged & intensive treatment may cause local atropic changes of the skin such as striae, thinning & dilatation of the superficial blood vessels, particularly when occlusive dressing is used or when skin folds are involved. Systemic absorption, sufficient to produce adrenal suppression, can occur with prolonged or extensive use, specially when napkin is used. Infants and children are particularly at risk. It should be exercised if a topical steroid is used near the eye Glaucoma might be the result if the preparation enters the eye.

Drug interaction

    Fusidic Acid may inhibit the metabolism of drugs which undergo extensive bio-transformation in the liver, but no evidence for this is available. Food may delay absorption of Fusidic Acid. No hazardous drug interactions are reported with topical hydrocortisone.

Use in special groups

    Use in Pregnancy & Lactation: Fusidic Acid & Hydrocortisone should not be used in pregnancy. Both of them have been detected in the breast milk, so nursing mothers are advised not to use the drug.


    Fusidate H Cream: Each tube contains 10g cream.