Lomefloxacin, a difluorioniated quinolone derivative, is a bacterial gyrase inhibitor, effective against gram positive and gram negative bacteria. Lomefloxacin interferes with bacterial DNA related processes like initiation, elongation and termination phases of replication, transcription, DNA repair, recombination, transposition, supercoling and relaxation of DNA, resulting in a rapid killing of sensitive bacteria. Cross-resistance has only been reported with other quinolones, but not with any other group of antibiotics. No clinical studies are available about the efficacy in case infections with chlamydia.


    Lomeflox Sterile Eye Drops: Each ml contains Lomefloxacin Hydrochloride INN equivalent to Lomefloxacin 3 mg.


    Bacterial infections, including conjunctivitis, keratitis, corneal ulcer, blepharitis and blepharo-conjunctivitis which are due to Lomefloxacin susceptible microorganisms.

Dosage & Administration

    Adults and children (above 1 year of age): Instill 2-3 times daily 1 drop into the lower conjunctival sac. At the beginning of the treatment application should be more frequent, apply 5 drops within 20 minutes or 1 drop every hour during 6-10 hours. Duration of the treatment: 7 to 9 days.


    Hypersensitivity to the active ingredient, to excipients, or to quinolones. No adverse effects were noted in children.

Warning & Precautions

    Long term treatment with antibiotic may enhance development of secondary fungal infections or may support growth of non-susceptible bacteria. Some isolated cases of phototoxicity have been reported after systemic but not after topical ophthalmic use of Lomefloxacin. Nevertheless, during treatment with Lomefloxacin intensive exposure to sunlight or UV-radiation should be avoided.

Side effects

    Slight and transient burning immediately after instillation of the eye drops has been reported in 4.7% of users. Although phototoxicity has not been reported after ophthalmic use. Since the following allergic reactions have been reported after systemic use of Lomefloxacin, they cannot be excluded after topical ophthalmic use: allergic reactions, asthma, dyspnoea, urticaria, erythema, pruritus and hypersensitization.

Drug interaction

    In order to avoid reduction of efficacy, no ophthalmic preparation containing heavy metals, such as zinc, should be used during 15 minutes preceding and following application of Lomeflox. Bacteriostatic ophthalmic antibiotics should not be used concomitantly with Lomefloxacin eye drops. Other interactions have not been described to date.

Use in special groups

    The drug should only be used when the benefit outweighs the potential risk for the foetus or the infant.


    Lomeflox Eye Drops: Each LDPE dropper bottle contains 5 ml sterile & pyrogen eye drops.