Indications

Napro is indicated in inflammatory rheumatic diseases, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, in soft tissue rheumatism & musculoskeletal disorders, acute gout, dysmenorrhoea etc.

Dosage & Administration

1. Rheumatic disorders: the usual initial dose of naproxen is 250 mg twice daily adjusted to 500 mg to 1000 mg daily in 2 divided doses.

2. Juvenile arthritis: A dose of 10 mg/kg body weight daily in 2 divided doses is used for children over 5 years of age.

3. Acute gout: An initial dose of 750 mg followed by 250 mg every 8 hours.

4. Dysmenorrhoea: 500 mg may be given initially followed by 250 mg in every 6-8 hours.

Contrainidications

History of asthma attacks or urticaria triggered by acetylsalicylic acid or other prostaglandin synthesis inhibitors.

Warning & Precautions

Use of Naproxen should be avoided in patients with gastrointestinal disorders and gastro-duodenal ulcer. In case of severe hepatic or renal damage or disturbance of cardiac function a close medical surveilance is indicated. Blood counts including platelet counts, as well as monitoring of hepatic and renal functions are recommended, particularly in patients under long-term therapy.

Side effects

Naproxen is generally well tolerated, but occasionally patient may complain gastric discomfort, nausea & dizziness. In exceptional cases, very sensitive patients may suffer from gastro-intestinal bleeding, skin rashes, thrombocytopenia.

Drug interaction

Antacid: The absorption of naproxen can be altered by antacids.
Aspirin: Plasma concentration of Naproxen can be reduced when aspirin is given concomitantly, this appeared to be due to increased exeretion of naproxen.
Diuretics: Naproxen diminish the effect of frusemide.
Probenecid: It increase the plasma concentration of Naproxen.

Use in special groups

Packing

Napro Tablet: Each box contains 50's tablets in blister pack.
Napro-500 Tablet: Each box contains 30's tablets in blister pack.