Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures.



    Xisol Hand Rub Solution: Each ml solution contains 0.5% w/v Chlorhexidine Gluconate (equivalent to 2.5% v/v Chlorhexidine Gluconate Solution BP) in 70% w/w Isopropyl Alcohol BP.


    For the disinfection of clean and intact skin. For pre-operative surgical hand disinfection, hand disinfection on the ward prior to aseptic procedures or after handling contaminated materials. For disinfection of the patients' skin prior to surgery or other invasive procedures.

Dosage & Administration

    Route of administration: For external use only.
    Adults: Pre-operative surgical hand disinfection - Dispense 5 ml of Xisol and spread thoroughly over both hands and forearms, rubbing vigorously. When dry apply a further 5 ml and repeat the procedure.
    Antiseptic hand disinfection on the ward - Dispense 3 ml of Xisol and spread thoroughly over the hands and wrists rubbing vigorously until dry.
    Disinfection of patients' skin - Prior to surgery apply Xisol to a sterile swab and rub vigorously over the operation site for a minimum of 2 minutes. Xisol is also used for preparation of the skin prior to invasive procedures such as venepuncture.
    Elderly and children: There are no special dosing regimens for children and the elderly.


    Xisol is contraindicated for persons who have previously shown a hypersensitivity reaction to chlorhexidine. However, such reactions are extremely rare.

Warning & Precautions

    For external use only. Avoid contact with the brain, meninges or middle ear. Not for injection. Do not use in body cavities.
    The solution is irritant to eyes and mucous membranes. Keep out of eyes. If chlorhexidine solutions come into contact with the eyes, wash out promptly and thoroughly with water.
    Flammable - this preparation contains alcohol: when use is to be followed by diathermy do not allow pooling of the fluid to occur, and ensure that the skin and surrounding drapes are dry.
    Prolonged skin contact with alcoholic solutions should be avoided, allow to dry before proceeding.

Side effects

    Irritative skin reactions can occasionally occur. Generalised allergic reactions have also been reported but are extremely rare.

Drug interaction

    Chlorhexidine is incompatible with soap and other anionic agents. Hypochlorite bleaches may cause brown stains to develop in fabrics, which have previously been in contact with preparations containing chlorhexidine.

Use in special groups

    Use in pregnancy and lactation: No untoward effects are known.


    Xisol Hand Rub Solution: Each plastic bottle contains 50 ml /250 ml solution.