Clobesol shows both local anti-inflammatory and immunosuppressive activity. The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin.
Clobesol has both local anti-inflammatory and immunosuppressive activity. The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. Clobesol also reduces the number of human leukocyte antigen & also inhibits phospholipase A2 activity via formation of lipocortin. Clobetasol reduces the formation of prostaglandins and leucotrienes in the local tissues.
Clobesol Cream: Each gram cream contains Clobetasol Propionate USP 0.5 mg.
Clobesol Ointment: Each gram ointment contains Clobetasol Propionate USP 0.5 mg.
- Initial control of all forms of hyperacute eczema in all age groups â€¢ Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen simplex
- Chronic hyperkeratotic psoriasis of any area of the body
- Severe acute photosensitivity
- Acute contact dermatitis
- Hypertropic lichen planus
- Localized bollous disorders
- Keloid scarring
- Pretiable myxoedema, Vitiligo, Suppression of reactions after cryotherapy.
Clobesol should be applied with gentle rubbing to the affected skin areas twice daily. Dosage should not normally exceed 50 g per week and the duration of a course should not be more than 4 weeks. The potency can further enhanced by the use of occlusive dressing.
- Cutaneous infections such as impetigo, tinea corporis and herpes simplex
- Infestations such as scabies
- Acne vulgaris
- Children under 1 year
- Gravitational ulceration
- Perioral dermatitis.
Avoid long-term therapy particularly in children, in whom adrenal suppression occurs readily. If Clobesol is required for use in children, it is recommended that the treatment should be weekly reviewed. Avoid prolonged application to face because the face than other area of the body exhibits more atrophic changes with potent corticosteroids. Discontinue the use if there is spread of infection. Avoid contact with eyes.
The use of large amounts of cream for a long period of time over very large areas of the body can lead to produce adrenal suppression, cushing syndrome; hypercorticism; pigmentation; atrophic changes, such as thinning, striae; etc.
No hazardous interactions have been found.
Use in pregnancy: Clobesol should be avoided in pregnant women.
Use in lactation: Mothers using large amounts of the drug should be aware of potential excretion in milk.
Use in Paediatrics: The drug may be used in paediatrics patients in appropriate dosage, but large quantities for prolonged period should be avoided. It is contraindicated in children less than one year.
Clobesol Cream: Each tube contains 10g cream
Clobesol Ointment: Each tube contains 10g ointment
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