Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. It also inhibits platelet aggregation. Tenoxicam inhibits prostaglandin biosynthesis. In-vitro tests of leukocyte peroxidase suggest that tenoxicam may act as a scavenger for active oxyegen at the site of inflammation. Tenoxicam is a potent in-vitro inhibitor of human metalloproteinases, which induce cartilage breakdown. These pharmacological effects explain, at least in part, the therapeutic benefit of tenoxicam in the treatment of painful inflammatory and degenerative disorders of the musculoskeletal system. Antipyretics may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.


    Xicotil Tablet: Each film coated tablet contains Tenoxicam BP 20 mg.


    Xicotil is indicated for the treatment of the painful inflammatory and degenerative disorders of the musculoskeletal system: rheumatoid arthritis, osteoarthritis, arthrosis, ankylosing spondylitis, extraarticular disorders, e.g. tendinitis, bursitis, periarthritis of shoulders (shoulder-hand syndrome) or hips, strains and sprains. It is also effective in post-operative pain, acute gout & primary dysmenorrhea.

Dosage & Administration

    Standard dose: For all indications except primary dysmenorrhoea, post-operative pain and acute gout, a daily dose of 20 mg should be given at the same time of day. Primary dysmenorrhoea: 20 to 40 mg once daily. Post-operative pain : 40 mg once daily up to five days: Acute attacks of gout: 40 mg once daily for two days followed by 20 mg once daily for a further five days. In chronic disorders, daily doses higher than 20 mg are not recommended.
    Special dosage Instruction: Dosage should be minimised in the elderly and in patients with renal impairment. Because of lack of clinical experience, no dosage recommendations have so far been established for children and adolescents. The tablets should be taken with a glass of water. It is preferable to take this medicine during or immediately after a meal.


    Tenoxicam is contraindicated in patients with known hypersensitivity to tenoxicam, to any component of the product or to other non-steroidal anti-inflammatory drugs (NSAIDs). Tenoxicam is relatively contraindicated in patients with liver dysfunction, asthma, GI bleeding and peptic ulcer.

Warning & Precautions

    Patients with uncontrolled hypertension, congestive heart failure, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease should only be treated with Tenoxicam after careful consideration. The use of tenoxicam with concomitant NSAIDs, including cyclooxygenase- 2 selective inhibitors should be avoided. NSAIDs should be given with care to patients with a history of IBD as their condition may be exacerabated. Caution is advised in patients receiving concomitnat medications which could increase the risk of ulceration or bleedings, such as oral corticosteroids, anticoagulants, SSRI or antiplatelets agents (e.g. Aspirin).

Side effects

    Tenoxicam is well tolerated in the recommended dosage. Usually the undesirable effects reported are mild and transient. These are gastrointestinal disorders: gastric, epigastric and abdominal discomfort, dyspepsia, heartburn, nausea; nervous system disorders: dizziness, headache. Vertigo, sleep disturbance, palpitation, urticaria may occur in rarely.

Drug interaction

    Concurent treatment with salicylates or other NSAIDs may increase the risk of undesirable reactions. There is an increased risk of gastrointestinal bleeding when anti platelet agents and selective serotoninreuptake inhibitors are combined with tenoxicam. Tenoxicam should not be administered concurrently with potassium sparing diuretics as they may cause hyperkalemia & renal failure. Tenoxicam may attenuate the antihypertensive effects of alpha-adrenergic blockers and ACE-inhibitors.

Use in special groups

    Use in Pregnancy: No data with tenoxicam exist in pregnant women.
    Use in Nursing mothers: Based on findings from single dose administration, a very small amount of tenoxicam passes into breast milk. There is no evidence of adverse reactions in breast-fed infants of mothers taking Tenoxicam. Nevertheless, infants should be weaned or the medicine discontinued.


    Xicotil Tablet: Each box contains 30's tablets in blister pack.