Clobetasol Propionate has both local anti-inflammatory and immunosuppressive activity. Salicylic acid is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle.
Clobetasol Propionate has both local anti-inflammatory and immunosuppressive activity. The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. It inhibits phospholipase A 2 activity via formation of lipocortin which reduces the formation of prostaglandins and leukotrienes in the local tissues. Salicylic acid is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle.
Clobesol SA Ointment: Each gram ointment contains Clobetasol Propionate USP 0.5 mg and Salicylic Acid BP 30 mg.
• Initial control of all forms of hyper acute eczema
• Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen-
simplex
• Chronic hyperkeratotic psoriasis
• Severe acute photosensitivity
• Acute contact dermatitis
• Hypertrophic lichen planus & lichen sclerosus
• Localized bullous disorders
• Keloid scarring
• Pretibial myxoedema, vitiligo, suppression of reactions after cryotherapy
• Seborrheic dermatitis of the scalp
Apply the ointment as thin layer to the affected area twice daily. Clobesol SA treatment should not be continued for more than 14 days.
Hypersensitivity to clobetasol propionate and salicylic acid.
Avoid contact with eyes, mouth, nose or mucus membrane.
Avoid occlusive dressing and application on the large surface area.
Clobetasol may cause thinning of epidermis, burning, itching, irritation etc. Salicylic acid may cause allergic reaction, hives etc.
No hazardous interactions have been found.
Use in pregnancy: This combination should be avoided in pregnant women.
Use in lactation: Mothers using large amounts of the drug should be aware of potential excretion in milk.
Paediatrics Use: This combination is contraindicated in patients below 12 years.
Clobesol SA Ointment: Each tube contains 10 /15 /20 g ointment.
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