ltopride Hydrochloride is a potent dopamine-2 antagonist and an acetylcholinesterase inhibitor. It increases acetylcholine concentrations by inhibiting dopamine D 2 receptors and acetylcholinesterase. Higher acetylcholine increases GI peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination. Itopa-50 is used to treat gastrointestinal symptoms in chronic gastritis (bloated feeling, upper abdominal pain, anorexia, heartburn, nausea, and vomiting) The unique mechanism (dual mode of action) of Itopa-50 ensures better efficacy than Domperidone in relieving functional dyspepsia. It provides better efficacy than Domperidone in combination with Rabeprazole in managing GERD symptoms. Moreover, Itopa-50 is safer than Domperidone as it doesn’t cause QT prolongation & cardiac arrhythmia.
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