Ivacard (Ivabradine INN) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker. It is a heart rate lowering agent that acts by selectively & specifically inhibiting the cardiac pacemaker current (if), a mixed sodium-potassium inward current that controls the spontaneous diastolic depolarization in the sinoatrial (SA) node and hence regulates the heart rate.
Ivacard (Ivabradine INN) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease patients. It also reduces the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure.
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